Synthesis of Mono and Bi Dentate Schiff’s Bases and their Complexes with M(CO)₆ [M= Cr, Mo, W]

Dr. Manoj Kumar Agarwal¹, Manish Kaushik² and Amit Singhal^3,*

¹Deptt. of Chemistry, Accurate Institute of Management & Technology, Greater Noida, G.B. Nagar, U.P., India

²Deptt. of Chemsitry, Accurate Institute of Management & Technology, Greater Noida, G.B. Nagar, U.P., India

^3,*Department of Chemical Sciences, JJT University, Jhunjhunu Rajasthan, India

The development of bacterial resistance to available antibiotics and increasing incidence of multi resistant bacterial infections in hospitals and in the community has necessitated the search for new antibacterial agents to treat the bacterial infection. Thiazoles and their derivatives form a part of Vitamin B₁ and coenzyme carboxylase. They represent a very interesting class of compounds because of their wide applications as antimicrobial, anti-inflammatory, anti-degenerative and anti-HIV activities. In the light of the above we have synthesized some new noble Schiff’s Bases and their G-6 metal carbonyl derivatives. Schiff’s bases  viz. N-[(E)-phenylmethylidene](naptho[1,2-d][1,3]thiazol-2-amine (SB¹), N-[(E)-(3-methoxyphenyl)methylidene](naptho[1,2-d][1,3]thiazol-2-amine) (SB²) react with G-6 metal hexacarbonyls in benzene to give monosubstituted derivatives  while N-[(E)-phenylmethylidene] (naptho[1,2-d][1,3]thiazol-2-ylimino)methyl]phenol  (SB³), 2-methoxy-6-[(E)-(naptho[1,2-d][1,3]thiazol-2-ylimino)methyl]phenol (SB⁴) and N-[(E)-furan-2-ylmethylidine] (naptho[1,2-d][1,3]thiazol-2-amine (SB⁵) react with G-6 metal hexacarbonyls in benzene to give disubstituted derivatives.

Keywords: Schiff bases, Metal carbonyl, Naptho[1,2-d][1,3]thiazol-2-amine.

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