Insulin-Mediated Signaling Pathways in Healthy State and Insulin Resistance State
Prof. (Dr.) Anil Gupta
Vice-principal, Professor and Head, Department of Biochemistry
Eklavya Dental College and Hospital, Kotputli, Rajasthan, India
Global burden of type 2 diabetes mellitus is the main focus of the research studies in the world to understand fine details of normal metabolic and Mitogenic actions of insulin coupled with minute knowledge of the molecular causes of the insulin resistance and defect in the insulin signaling pathways that contribute to impaired carbohydrate metabolism in body. This review article provides thorough description of the insulin mediated signaling pathways and role of implicated effector molecules that are part of impaired signaling pathways to reach a consensus helpful in developing newer diagnostic as well as therapeutic molecules.
Keywords: Type 2 diabetes, insulin resistance, insulin actions, insulin signaling, impaired insulin signaling.
