A Review on Systematic Study of Aryl Propionic Acid and Derivatives
Deepika Katariya1,* and Ajit Joshi2
1,2Department of Chemistry, Mewar University, Chittorgarh (Rajasthan)
E-mail:deepika.katariya65@gmail.com
In aryl propionic acid most common drugs are ibuprofen, ketoprophen and naproxen. These are available over-the-counter in United States. A consumer report noted that ibuprofen, naproxen, and salsalate are less expensive than other NSAIDs, and essentially as effective and safe when used appropriately to treat osteoarthritis and pain. Ibuprophen (Motrin®, Advil®, Motrin IB®) is considered to be among the safest NSAIDs and is generally well tolerated but can, nevertheless, rarely cause clinically apparent and serious acute liver. Ketoprophen (Orudis,Oruvail) topical plasters are being extensively used for treatment of musculoskeletal pain. Ketoprofen is used for its antipyretic, analgesic, and anti-inflammatory properties. Naproxen (Naprosyn®, Aleve®) is commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions including migraine, osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis and bursitis.
In general, there exists virtually very little difference between the therapeutic efficacy of different NSAIDs, as certain patients would respond to one ‘drug’ better than another. In reality, it is almost difficult to predict the best suitable drug for a patient; thus, it invariably necessitates to arrive at the best-fit-drug via trial and error only. By studying these drugs we can get the knowledge about these drugs like how these drugs are useful and harmful for us.
Keywords: Aryl propionic acid, Ibuprofen, Ketoprofen,Neproxen, Non-steroidal anti-inflammatory drugs (NSAIDs) and Inflammation.
