A Comparative Study of Novel Super Disintegrating Agent, Guar gum to existing Super Disintegrating Agent, Sodium Starch Glycolate on Release Rate of Drug from Fast Dissolving Tablet
Dr. Rambabu Sharma1, *, Deepak Choudhary2, Anil Bhandari3, Rajesh Verma4 and M.S. Ranawat5
1,2,3,4Faculty of pharmaceutical science, Jodhpur National University, Jodhpur, India.
5B. N. College of Pharmacy, Udaipur. India.
The aim of present study is to exist a novel super disintegrants in fast dissolving tablet. Guar gum is a natural substance and used in many pharmaceutical product and it can also used as a super disintegrating agent in fast dissolving tablet. The result is that it released the 99.21% drug in 15min as compared to Sodium Starch Glycolate (SSG), where only 97.51% drug was released. The onset of time was better for guar gum where, 84.79% of drug was released in 2min from F3 formulation as compared of F6 formulation where only 71.22% drug was released. The possible mechanism of disintegrating property was good swelling property of guar gum than SSG but when the concentration of guar gum was used above 8%, it created a problem on disintegration of tablet due to formation of gel layer around the tablet. All evaluating parameters were within range and no markedly difference was observed.
